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NoRC associated RNA
NoRC associated RNA (also known as pRNA) is a non-coding RNA element which regulates ribosomal RNA transcription by interacting with TIP5, part of the NoRC chromatin remodeling complex.
==Function and genomic context==
Ribosomal RNA genes (rDNA) encodes for ribosomal RNA (rRNA) that constitutes the majority of the ribosome. These genes are not constitutively expressed and a mechanism of gene silencing is put in place to suppress rDNA gene expression when the ribosome isn’t required. Gene silencing of rDNA requires binding of the chromatin remodelling complex, NoRC to a non-coding RNA (ncRNA) molecule that is complementary to the rDNA promoter.
The ncRNA that is involved in rDNA silencing is known as pRNA and has been shown to originate from a spacer promoter located upstream of the pre-ribosomal RNA transcription start site. Once this ncRNA is transcribed it is processed to form a 150-250 nucleotide long RNA molecule and overlaps the rDNA promoter region. Computational analysis of pRNA predicted that pRNA forms a conserved stem loop structure and is shown to be conserved across a number eukaryotes.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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